High-resolution 3D imaging of biological samples allowing the visualisation of cells in real time in order to better understand their functionning.

Photopolymerizable silver-based coating with anticorrosive and antimicrobial properties : promising alternative to chromate-based coatings, which are carcinogenic and mutagenic and increasingly limited by REACH regulations.

The sliding β-clamp, a ring shaped dimer that encircles dsDNA, and the protein-protein interactions in bacterial replication are extremely well conserved and represents an attractive target for the design of new antibiotics.
This project aims at developing, optimizing, and evaluating a series of 5 aa residues peptides targeting the sliding β-clamp in an in-vivo model of gram-negative infection.

New Chemical Entity with neutraligand activity on CXCL12
New way to modulate Immune response and inflammation in various clinical settings, including auto-immune diseases and inflammatory pain. 
Sub-micromolar affinity, promising in-vitro ADME parameters and oral bioavailability. 

A robust catalytic hydrogel platform for (bio)catalysis on a polymer foam. An innovative method of enzyme or other catalyst immobilization, particularly adapted to flow chemistry.

A low-cost, easy and efficient method for the tip molding of small bend radius fiber. As a result, microlenses 4-200 µm with revolutionary symetry. The applications of such fibres are in telecommunications, endoscopy, microscopy and low flow imaging (ultra-fast cameras etc.).

New potential targets identified to restore intracellular cholesterol transport in the treatment of lysosomal storage diseases with cholesterol accumulation. Creation of a library of compounds based on the targets of interest. Identify molecules that regulate intracellular cholesterol transport by functional screening.

An improved way of turbidity measurment, especially in high turbid medium is essential for quality control. While improving and multiplying the measured parameters, the technology reduces also the clogging and saturation of turbidimeters.

Probe which can be functionalized with different ligands (peptides, small molecules, antibodies) to target membrane receptors (GPCRs among others) and to visualize them by fluorescence in vitro and in vivo. The probe combined with the ligand becomes fluorescent and lights up only by binding to the targeted receptor on a "turn on" principle. Very powerful GPCRs 'imaging and screening tool.

Development of a new non-invasive monitoring tool based on urinary biomarkers of kidney graft stability. Use of a targeted proteomic analysis strategy to validate new urinary peptide biomarkers from 30 proteins with differentiated expression in stable patients and in patients with complications.